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Cellosaurus HB1.F3.Ras (CVCL_LJ48)

[Text version]
Cell line name HB1.F3.Ras
Synonyms F3.Ras
Accession CVCL_LJ48
Resource Identification Initiative To cite this cell line use: HB1.F3.Ras (RRID:CVCL_LJ48)
Comments Characteristics: Tumorigenic, forms brain cancers when injected in mouse brains.
Transfected with: HGNC; 5173; HRAS (with p.Gly12Val).
Transfected with: UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: v-Myc.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Fetal brain, telencephalon; UBERON=UBERON_0014371.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_LJ44 (HB1.F3)
Sex of cell Female
Age at sampling 14FW
Category Transformed cell line
Publications

PubMed=21755312; DOI=10.1007/s12015-011-9280-4
Lee J.-S., Lee H.J., Moon B.-H., Song S.-H., Lee M.-O., Shim S.H., Kim H.S., Lee M.C., Kwon J.T., Fornace A.J. Jr., Kim S.U., Cha H.J.
Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation.
Stem Cell Rev. Rep. 8:532-545(2012)

PubMed=25096191; DOI=10.1093/neuonc/nou145
Lee J.-S., Park J.-R., Kwon O.-S., Lee T.-H., Nakano I., Miyoshi H., Chun K.-H., Park M.-J., Lee H.J., Kim S.U., Cha H.-J.
SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of 'cancer cells with neural stemness' in a p53-dependent manner.
Neuro-oncol. 17:95-106(2015)

Cross-references
Encyclopedic resources Wikidata; Q54881356
Entry history
Entry creation15-Nov-2017
Last entry update29-Jun-2023
Version number7