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Cellosaurus C106 [Human rectal adenocarcinoma] (CVCL_M011)

[Text version]

Cell line name C106 [Human rectal adenocarcinoma]
Accession CVCL_M011
Resource Identification Initiative To cite this cell line use: C106 [Human rectal adenocarcinoma] (RRID:CVCL_M011)
Comments Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: Transcriptome analysis.
Sequence variations APC p.Gln1237fs*2 (c.3709_3710delCA) and p.His1490fs*17 (c.4469delA) (PubMed=24755471).
KRAS p.Gly12Cys (c.34G>T) (PubMed=24755471).
TP53 p.Thr125Met (c.374C>T) (PubMed=16418264).
Disease Rectal adenocarcinoma (NCIt: C9383)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 78Y
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=25926053

Markers:
AmelogeninX
CSF1PO10,11
D5S81812
D7S8208,10
D13S3178,14
D16S53912,13
D21S1132.2
TH016
TPOX10,11
vWA18

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Publications

PubMed=10051639; DOI=10.1073/pnas.96.5.2316
Efstathiou J.A., Liu D., Wheeler J.M., Kim H.C., Beck N.E., Ilyas M., Karayiannakis A.J., Mortensen N.J., Kmiot W., Playford R.J., Pignatelli M., Bodmer W.F.
Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.
Proc. Natl. Acad. Sci. U.S.A. 96:2316-2321(1999)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352
Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J., Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=16418264; DOI=10.1073/pnas.0510146103
Liu Y., Bodmer W.F.
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105
Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

PubMed=29101300; DOI=10.15252/msb.20177701
Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R., Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S., Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J., Weichert W., Knapp S., Feller S.M., Kuster B.
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Cell line collections ECACC; 12022906
Ximbio; 151762
Cell line databases/resources ColonAtlas; C106
Gene expression databases GEO; GSM1346861
GEO; GSM1374419
GEO; GSM1448197
Other Wikidata; Q54807830
Polymorphism and mutation databases Cosmic; 948836
Cosmic; 986002
Cosmic; 995375
Cosmic; 1312289
Cosmic; 2301956
IARC_TP53; 21733
Proteomic databases PRIDE; PXD005354
Entry history
Entry creation06-May-2013
Last entry updated25-Feb-2019
Version number16