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Cellosaurus LNCaP 104-S (CVCL_M126)

[Text version]

Cell line name LNCaP 104-S
Synonyms LNCaP-104S; LNCaP 104S; LNCaP104S; 104-S
Accession CVCL_M126
Resource Identification Initiative To cite this cell line use: LNCaP 104-S (RRID:CVCL_M126)
Sequence variations Homozygous for AR p.Thr878Ala (c.2632A>G) (from parent cell line).
Heterozygous for MEN1 p.Tyr313Ter (c.939T>A) (from parent cell line).
Heterozygous for PIK3R1 p.Arg639Ter (c.1915C>T) (from parent cell line).
PTEN p.Lys6Argfs*4 (c.17_18delAA) (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Children:
CVCL_M127 (LNCaP 104-R1)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=7511045
Kokontis J.M., Takakura K., Hay N., Liao S.
Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation.
Cancer Res. 54:1566-1573(1994)

PubMed=9658399; DOI=10.1210/mend.12.7.0136
Kokontis J.M., Hay N., Liao S.
Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest.
Mol. Endocrinol. 12:941-953(1998)

PubMed=16015608; DOI=10.1002/pros.20285
Kokontis J.M., Hsu S., Chuu C.P., Dang M., Fukuchi J., Hiipakka R.A., Liao S.
Role of androgen receptor in the progression of human prostate tumor cells to androgen independence and insensitivity.
Prostate 65:287-298(2005)

Cross-references
Gene expression databases GEO; GSM525801
Other Wikidata; Q54902811
Polymorphism and mutation databases Cosmic; 2580129
Entry history
Entry creation06-May-2013
Last entry update02-Jul-2020
Version number11