ID   LNCaP 104-S
AC   CVCL_M126
SY   LNCaP-104S; LNCaP 104S; LNCaP104S; 104-S
DR   cancercelllines; CVCL_M126
DR   Cosmic; 2580129
DR   GEO; GSM525801
DR   Wikidata; Q54902811
RX   PubMed=7511045;
RX   PubMed=9658399;
RX   PubMed=16015608;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0395 ! LNCaP
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 05-10-23; Version: 17
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RX   PubMed=7511045;
RA   Kokontis J.M., Takakura K., Hay N., Liao S.-T.;
RT   "Increased androgen receptor activity and altered c-myc expression in
RT   prostate cancer cells after long-term androgen deprivation.";
RL   Cancer Res. 54:1566-1573(1994).
//
RX   PubMed=9658399; DOI=10.1210/mend.12.7.0136;
RA   Kokontis J.M., Hay N., Liao S.-T.;
RT   "Progression of LNCaP prostate tumor cells during androgen
RT   deprivation: hormone-independent growth, repression of proliferation
RT   by androgen, and role for p27Kip1 in androgen-induced cell cycle
RT   arrest.";
RL   Mol. Endocrinol. 12:941-953(1998).
//
RX   PubMed=16015608; DOI=10.1002/pros.20285;
RA   Kokontis J.M., Hsu S., Chuu C.-P., Dang M., Fukuchi J., Hiipakka R.A.,
RA   Liao S.-T.;
RT   "Role of androgen receptor in the progression of human prostate tumor
RT   cells to androgen independence and insensitivity.";
RL   Prostate 65:287-298(2005).
//