Cellosaurus cell line LNCaP C-81 (CVCL_M131)

• Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  
• Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
  

PubMed=11705865
Karan D., Schmied B.M., Dave B.J., Wittel U.A., Lin M.-F., Batra S.K.
Decreased androgen-responsive growth of human prostate cancer is associated with increased genetic alterations.
Clin. Cancer Res. 7:3472-3480(2001)

PubMed=11870800; DOI=10.1002/pros.10054
Igawa T., Lin F.-F., Lee M.-S., Karan D., Batra S.K., Lin M.-F.
Establishment and characterization of androgen-independent human prostate cancer LNCaP cell model.
Prostate 50:222-235(2002)

PubMed=17977648; DOI=10.1016/j.canlet.2007.09.018
Singh A.P., Bafna S., Chaudhary K., Venkatraman G., Smith L., Eudy J.D., Johansson S.L., Lin M.-F., Batra S.K.
Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells.
Cancer Lett. 259:28-38(2008)