ID   LNCaP C5
AC   CVCL_M132
SY   LNCaP-C5; LNCaP subline C5; C5
DR   cancercelllines; CVCL_M132
DR   Wikidata; Q54902822
RX   PubMed=8169003;
RX   PubMed=35502546;
WW   https://en.wikipedia.org/wiki/LNCaP
CC   Population: Caucasian.
CC   Characteristics: Derived from a tumor that developed in castrated nude mice injected with LNCaP cells.
CC   Sequence variation: Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0395 ! LNCaP
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 05-10-23; Version: 17
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RX   PubMed=8169003; DOI=10.1002/ijc.2910570319;
RA   Wu H.-C., Hsieh J.-T., Gleave M.E., Brown N.M., Pathak S.,
RA   Chung L.W.K.;
RT   "Derivation of androgen-independent human LNCaP prostatic cancer cell
RT   sublines: role of bone stromal cells.";
RL   Int. J. Cancer 57:406-412(1994).
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RX   PubMed=35502546; DOI=10.1158/0008-5472.CAN-22-1065;
RA   Abate-Shen C., Nunes de Almeida F.;
RT   "Establishment of the LNCaP cell line -- the dawn of an era for
RT   prostate cancer research.";
RL   Cancer Res. 82:1689-1691(2022).
//