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Cellosaurus SJ-GBM2 (CVCL_M141)

[Text version]
Cell line name SJ-GBM2
Synonyms SJ-GBM-2; SJGBM2; SJ-G2; SJG2
Accession CVCL_M141
Resource Identification Initiative To cite this cell line use: SJ-GBM2 (RRID:CVCL_M141)
Comments Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
Population: Caucasian.
Doubling time: 29 hours (PubMed=20922763).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Homozygous (CelloPub=CLPUB00738; PubMed=9802058).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): COG; PubMed=20922763

Markers:
AmelogeninX
CSF1PO12
D2S133817,24
D3S135815
D5S81812
D7S82012
D8S11798,12
D13S31711,12
D16S53911
D18S5116,17
D19S43312,14
FGA24
TH016,9.3
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Web pages https://www.cccells.org/PDF_Files/Brain/SJ-GBM2.pdf
https://www.cccells.org/tables/Brain.php
http://www.pptpinvitro.org/cell_lines_panel.php
Publications

PubMed=7634381; DOI=10.1007/BF00686188
Houghton P.J., Cheshire P.J., Hallman J.D. II, Lutz L., Friedman H.S., Danks M.K., Houghton J.A.
Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors.
Cancer Chemother. Pharmacol. 36:393-403(1995)

CLPUB00738
Nitiss K.C.
Oncogenic changes and induction of differentiation in pediatric astrocytic cell lines.
Thesis PhD (1997), University of Southern California Los Angeles, United States

PubMed=9220028; DOI=10.1016/S0303-7207(97)00080-4
Sharif T.R., Luo W., Sharif M.
Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway.
Mol. Cell. Endocrinol. 130:119-130(1997)

PubMed=9802058
McPake C.R., Tillman D.M., Poquette C.A., George E.O., Houghton J.A., Harris L.C.
Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status.
Oncol. Res. 10:235-244(1998)

PubMed=10402232; DOI=10.3892/ijo.15.2.237
Sharif T.R., Sharif M.
Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.
Int. J. Oncol. 15:237-243(1999)

PubMed=10933967; DOI=10.1006/mthe.2000.0064
Pawlik C.A., Iyengar R.V., Krull E.J., Mason S.E., Khanna R., Harris L.C., Potter P.M., Danks M.K., Guichard S.M.
Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11.
Mol. Ther. 1:457-463(2000)

PubMed=11306486
Iyengar R.V., Pawlik C.A., Krull E.J., Phelps D.A., Burger R.A., Harris L.C., Potter P.M., Danks M.K.
Use of a modified ornithine decarboxylase promoter to achieve efficient c-MYC- or N-MYC-regulated protein expression.
Cancer Res. 61:3045-3052(2001)

PubMed=20922763; DOI=10.1002/pbc.22801
Kang M.H., Smith M.A., Morton C.L., Keshelava N., Houghton P.J., Reynolds C.P.
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Pediatr. Blood Cancer 56:239-249(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M141
Anatomy/cell type resources BTO; BTO:0006332
Encyclopedic resources Wikidata; Q54953524
Polymorphism and mutation databases IARC_TP53; 24985
Entry history
Entry creation06-May-2013
Last entry update05-Oct-2023
Version number15