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Cellosaurus HC-AFW1 (CVCL_M172)

[Text version]
Cell line name HC-AFW1
Synonyms HCAFW1
Accession CVCL_M172
Resource Identification Initiative To cite this cell line use: HC-AFW1 (RRID:CVCL_M172)
Comments Doubling time: 40 hours (PubMed=22666492).
Omics: CNV analysis.
Sequence variations
  • Gene deletion; HGNC; 2625; CYP2D6; Zygosity=Heterozygous (PubMed=26310804).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Val22_Phe70del; Zygosity=Heterozygous (PubMed=22666492).
Disease Childhood hepatocellular carcinoma (NCIt: C7955)
Pediatric hepatocellular carcinoma (ORDO: Orphanet_33402)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 4Y6M
Category Cancer cell line
Publications

PubMed=22666492; DOI=10.1371/journal.pone.0038223
Armeanu-Ebinger S., Wenz J., Seitz G., Leuschner I., Handgretinger R., Mau-Holzmann U.A., Bonin M., Sipos B., Fuchs J., Warmann S.W.
Characterisation of the cell line HC-AFW1 derived from a pediatric hepatocellular carcinoma.
PLoS ONE 7:E38223-E38223(2012)

PubMed=26310804; DOI=10.1124/dmd.115.064667
Braeuning A., Thomas M., Hofmann U., Vetter S., Zeller E., Petzuch B., Johanning J., Schroth W., Weiss T.S., Zanger U.M., Schwarz M.
Comparative analysis and functional characterization of HC-AFW1 hepatocarcinoma cells: cytochrome P450 expression and induction by nuclear receptor agonists.
Drug Metab. Dispos. 43:1781-1787(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M172
Encyclopedic resources Wikidata; Q54881474
Gene expression databases GEO; GSE29283
Polymorphism and mutation databases Progenetix; CVCL_M172
Entry history
Entry creation06-May-2013
Last entry update05-Oct-2023
Version number14