ID   MMNK-1
AC   CVCL_M266
SY   MMNK1
DR   JCRB; JCRB1554
DR   Wikidata; Q54906231
RX   PubMed=14966424;
RX   PubMed=21871105;
RX   PubMed=27231123;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, Japanese National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology; FERM BP-8126.
CC   Population: Japanese.
CC   Characteristics: Because it has been transduced by a construct containing LoxP sites, transfection with the Cre recombinase eliminates the SV40 T gene thus reverting the cells to a non-immortal phenotype.
CC   Characteristics: Transduced with a retroviral vector SSR#197 (MoMLV/LTR-LoxP-hTERT-IRES-EGFP-LoxP-MoMLV/LTR) expressing hTERT and eGFP flanked by a pair of loxP sites.
CC   Transfected with: HGNC; 11730; TERT.
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=pSV3-neo].
CC   Derived from site: In situ; Fetal liver; UBERON=UBERON_0002107.
ST   Source(s): JCRB
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 9,12
ST   D16S539: 11,13
ST   D5S818: 11,15
ST   D7S820: 8,9
ST   TH01: 7,9
ST   TPOX: 8,11
ST   vWA: 14,17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_9131 ! OUMS-21 [1993]
SX   Sex unspecified
AG   18FW
CA   Telomerase immortalized cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 19
//
RX   PubMed=14966424; DOI=10.1097/01.TP.0000110292.73873.25;
RA   Maruyama M., Kobayashi N., Westerman K.A., Sakaguchi M., Allain J.-E.,
RA   Totsugawa T., Okitsu T., Fukazawa T., Weber A., Stolz D.B.,
RA   Leboulch P., Tanaka N.;
RT   "Establishment of a highly differentiated immortalized human
RT   cholangiocyte cell line with SV40T and hTERT.";
RL   Transplantation 77:446-451(2004).
//
RX   PubMed=21871105; DOI=10.1186/1476-4598-10-102;
RA   Obchoei S., Weakley S.M., Wongkham S., Wongkham C., Sawanyawisuth K.,
RA   Yao Q.-Z., Chen C.-Y.;
RT   "Cyclophilin A enhances cell proliferation and tumor growth of liver
RT   fluke-associated cholangiocarcinoma.";
RL   Mol. Cancer 10:102.1-102.15(2011).
//
RX   PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442;
RA   Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C.,
RA   Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K.,
RA   Greninger P., McDermott U., Garnett M.J., Jenkins R.L.,
RA   Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y.,
RA   Goyal L., Ferrone C.R., Zhu A.X., Joung J.K., Shokat K.M., Benes C.H.,
RA   El-Bardeesy N.;
RT   "Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity
RT   and SRC dependence in intrahepatic cholangiocarcinoma.";
RL   Cancer Discov. 6:727-739(2016).
//