ID   MCF-7/Taxol
AC   CVCL_M355
DR   cancercelllines; CVCL_M355
DR   Wikidata; Q54904387
RX   PubMed=20926015;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 17
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RX   PubMed=20926015; DOI=10.1177/147323001003800424;
RA   Zuo K.-Q., Zhang X.-P., Zou J., Li D., Lv Z.-W.;
RT   "Establishment of a paclitaxel resistant human breast cancer cell
RT   strain (MCF-7/Taxol) and intracellular paclitaxel binding protein
RT   analysis.";
RL   J. Int. Med. Res. 38:1428-1435(2010).
//