ID   MCF7/D40
AC   CVCL_M437
SY   MCF-7/D40; MCF-7 Dox40
DR   cancercelllines; CVCL_M437
DR   Wikidata; Q54904467
RX   PubMed=1676902;
RX   PubMed=10825126;
RX   PubMed=11309308;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 17
//
RX   PubMed=1676902; DOI=10.1038/bjc.1991.202;
RA   Taylor C.W., Dalton W.S., Parrish P.R., Gleason-Guzman M.C.,
RA   Bellamy W.T., Thompson F.H., Roe D.J., Trent J.M.;
RT   "Different mechanisms of decreased drug accumulation in doxorubicin
RT   and mitoxantrone resistant variants of the MCF7 human breast cancer
RT   cell line.";
RL   Br. J. Cancer 63:923-929(1991).
//
RX   PubMed=10825126;
RA   Scheffer G.L., Maliepaard M., Pijnenborg A.C.L.M., van Gastelen M.A.,
RA   de Jong M.C., Schroeijers A.B., van der Kolk D.M., Allen J.D.,
RA   Ross D.D., van der Valk P., Dalton W.S., Schellens J.H.M.,
RA   Scheper R.J.;
RT   "Breast cancer resistance protein is localized at the plasma membrane
RT   in mitoxantrone- and topotecan-resistant cell lines.";
RL   Cancer Res. 60:2589-2593(2000).
//
RX   PubMed=11309308;
RA   Maliepaard M., Scheffer G.L., Faneyte I.F., van Gastelen M.A.,
RA   Pijnenborg A.C.L.M., Schinkel A.H., van de Vijver M.J., Scheper R.J.,
RA   Schellens J.H.M.;
RT   "Subcellular localization and distribution of the breast cancer
RT   resistance protein transporter in normal human tissues.";
RL   Cancer Res. 61:3458-3464(2001).
//