Cellosaurus cell line MCF7/Mitox (CVCL_M438)

• Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  

PubMed=1676902; DOI=10.1038/bjc.1991.202
Taylor C.W., Dalton W.S., Parrish P.R., Gleason-Guzman M.C., Bellamy W.T., Thompson F.H., Roe D.J., Trent J.M.
Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line.
Br. J. Cancer 63:923-929(1991)

PubMed=10825126
Scheffer G.L., Maliepaard M., Pijnenborg A.C.L.M., van Gastelen M.A., de Jong M.C., Schroeijers A.B., van der Kolk D.M., Allen J.D., Ross D.D., van der Valk P., Dalton W.S., Schellens J.H.M., Scheper R.J.
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines.
Cancer Res. 60:2589-2593(2000)

PubMed=11309308
Maliepaard M., Scheffer G.L., Faneyte I.F., van Gastelen M.A., Pijnenborg A.C.L.M., Schinkel A.H., van de Vijver M.J., Scheper R.J., Schellens J.H.M.
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
Cancer Res. 61:3458-3464(2001)