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Cellosaurus MCF-7/E6 (CVCL_M439)

[Text version]

Cell line name MCF-7/E6
Synonyms MCF7-E6; MCF 7 E6
Accession CVCL_M439
Resource Identification Initiative To cite this cell line use: MCF-7/E6 (RRID:CVCL_M439)
Comments Transfected with: UniProtKB; P03126; Human papillomavirus type 16 (HPV16) protein E6.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

Fan S., Smith M.L., Rivet D.J. II, Duba D., Zhan Q., Kohn K.W., Fornace A.J. Jr., O'Connor P.M.
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
Cancer Res. 55:1649-1654(1995)

Other Wikidata; Q54904362
Entry history
Entry creation05-Nov-2013
Last entry update02-Jul-2020
Version number13