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Cellosaurus MCF-7/E6 (CVCL_M439)

[Text version]
Cell line name MCF-7/E6
Synonyms MCF7-E6; MCF 7 E6
Accession CVCL_M439
Resource Identification Initiative To cite this cell line use: MCF-7/E6 (RRID:CVCL_M439)
Comments Population: Caucasian.
Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=7712469
Fan S.-J., Smith M.L., Rivet D.J. II, Duba D.E., Zhan Q.-M., Kohn K.W., Fornace A.J. Jr., O'Connor P.M.
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
Cancer Res. 55:1649-1654(1995)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M439
Encyclopedic resources Wikidata; Q54904362
Entry history
Entry creation05-Nov-2013
Last entry update05-Oct-2023
Version number20