ID   105KC
AC   CVCL_M605
SY   105 KC; KC
DR   EFO; EFO_0006354
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03470879
DR   EGA; EGAS00001000610
DR   PharmacoDB; 105KC_1_2019
DR   Wikidata; Q54399871
RX   PubMed=2045389;
RX   PubMed=10906887;
RX   PubMed=12354749;
RX   PubMed=16039953;
RX   PubMed=25485619;
RX   PubMed=25877200;
CC   Doubling time: 36 hours (PubMed=16039953).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Miscellaneous: STR profile established at MicroSynth from personal communication of Muff R.
CC   Derived from site: In situ; Bone, distal femur; UBERON=UBERON_0004406.
ST   Source(s): Microsynth; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 8 (Microsynth)
ST   D13S317: 8,11 (PubMed=25877200)
ST   D16S539: 9,12,14 (PubMed=25877200)
ST   D16S539: 9,14 (Microsynth)
ST   D18S51: 15,16 (Microsynth)
ST   D18S51: 15,19 (PubMed=25877200)
ST   D21S11: 31.2,32.2
ST   D3S1358: 15,17
ST   D5S818: 10,11
ST   D7S820: 10,13
ST   D8S1179: 13,16
ST   FGA: 21,23 (PubMed=25877200)
ST   FGA: 23 (Microsynth)
ST   Penta D: 13
ST   Penta E: 5,20
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 15,18
DI   NCIt; C2946; Chondrosarcoma
DI   ORDO; Orphanet_55880; Chondrosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   66Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 19
//
RX   PubMed=2045389;
RA   Block J.A., Inerot S.E., Gitelis S., Kimura J.H.;
RT   "Synthesis of chondrocytic keratan sulphate-containing proteoglycans
RT   by human chondrosarcoma cells in long-term cell culture.";
RL   J. Bone Joint Surg. Am. 73:647-658(1991).
//
RX   PubMed=10906887; DOI=10.1097/00003086-200007000-00038;
RA   Scully S.P., Berend K.R., Toth A., Qi W.-N., Qi Z., Block J.A.;
RT   "Interstitial collagenase gene expression correlates with in vitro
RT   invasion in human chondrosarcoma.";
RL   Clin. Orthop. Relat. Res. 376:291-303(2000).
//
RX   PubMed=12354749;
RA   Martin J.A., Forest E., Block J.A., Klingelhutz A.J., Whited B.,
RA   Gitelis S., Wilkey A., Buckwalter J.A.;
RT   "Malignant transformation in human chondrosarcoma cells supported by
RT   telomerase activation and tumor suppressor inactivation.";
RL   Cell Growth Differ. 13:397-407(2002).
//
RX   PubMed=16039953; DOI=10.1016/j.canlet.2004.11.022;
RA   Schorle C.M., Finger F., Zien A., Block J.A., Gebhard P.M., Aigner T.;
RT   "Phenotypic characterization of chondrosarcoma-derived cell lines.";
RL   Cancer Lett. 226:143-154(2005).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//