ID   UROtsa/F35
AC   CVCL_M721
DR   cancercelllines; CVCL_M721
DR   Wikidata; Q54991845
RX   PubMed=16102566;
RX   PubMed=23691160;
CC   Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=23691160).
CC   Population: Caucasian; Swedish.
CC   Sequence variation: Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0554 ! T24
SX   Female
AG   82Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 17
//
RX   PubMed=16102566; DOI=10.1016/j.taap.2004.12.007;
RA   Drobna Z., Waters S.B., Devesa V., Harmon A.W., Thomas D.J.,
RA   Styblo M.;
RT   "Metabolism and toxicity of arsenic in human urothelial cells
RT   expressing rat arsenic (+3 oxidation state)-methyltransferase.";
RL   Toxicol. Appl. Pharmacol. 207:147-159(2005).
//
RX   PubMed=23691160; DOI=10.1371/journal.pone.0064139;
RA   Johnen G., Rozynek P., von der Gathen Y., Bryk O., Zdrenka R.,
RA   Johannes C., Weber D.G., Igwilo-Okuefuna O., Raiko I., Hippler J.,
RA   Bruning T., Dopp E.;
RT   "Cross-contamination of a UROtsa stock with T24 cells -- molecular
RT   comparison of different cell lines and stocks.";
RL   PLoS ONE 8:E64139-E64139(2013).
//