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Cellosaurus 50B11 (CVCL_M745)

Cell line name 50B11
Accession CVCL_M745
Resource Identification Initiative To cite this cell line use: 50B11 (RRID:CVCL_M745)
Comments Characteristics: Differentiation into neurons with nociceptive properties can be accomplished by using forskolin (PubMed=17565537).
Transfected with: HGNC; 11730; TERT.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Dorsal root ganglion; UBERON=UBERON_0000044.
Cell type: Neuron; CL=CL_0000540.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Hierarchy Children:
CVCL_C1LC (50B11 clone D4W)CVCL_C1LD (50B11 clone E4)
Sex of cell Sex unspecified
Age at sampling 14-15FD
Category Transformed cell line
Publications

PubMed=17565537; DOI=10.1111/j.1529-8027.2007.00131.x
Chen W.-R., Mi R.-F., Haughey N., Oz M., Hoke A.
Immortalization and characterization of a nociceptive dorsal root ganglion sensory neuronal line.
J. Peripher. Nerv. Syst. 12:121-130(2007)

PubMed=24269872; DOI=10.1016/j.neulet.2013.11.018
Bhattacherjee A., Liao Z.-H., Smith P.G.
Trophic factor and hormonal regulation of neurite outgrowth in sensory neuron-like 50B11 cells.
Neurosci. Lett. 558:120-125(2014)

PubMed=32636736; DOI=10.3389/fncel.2020.00184
Haberberger R.V., Barry C.M., Matusica D.
Immortalized dorsal root ganglion neuron cell lines.
Front. Cell. Neurosci. 14:184.1-184.21(2020)

PubMed=33307981; DOI=10.1177/1744806920970368
Matusica D., Canlas J., Martin M.A., Wei Y.-K., Marri S., Erickson A., Barry C.M., Brierley S.M., Best O.G., Michael M.Z., Voelcker N.H., Keating D.J., Haberberger R.V.
Differentiation of the 50B11 dorsal root ganglion cells into NGF and GDNF responsive nociceptor subtypes.
Mol. Pain 16:1744806920970368.1-1744806920970368.20(2020)

PubMed=35782611; DOI=10.1016/j.ymgmr.2022.100871
Kaneski C.R., Hanover J.A., Schueler Hoffman U.H.
Generation of an in vitro model for peripheral neuropathy in Fabry disease using CRISPR-Cas9 in the nociceptive dorsal root ganglion cell line 50B11.
Mol. Genet. Metab. Rep. 31:100871.1-100871.8(2022)

Cross-references
Encyclopedic resources Wikidata; Q54603686
Gene expression databases GEO; GSE147186
Entry history
Entry creation05-Nov-2013
Last entry update29-Jun-2023
Version number10