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Cellosaurus U1/HIV-1 (CVCL_M769)

[Text version]

Cell line name U1/HIV-1
Synonyms U1
Accession CVCL_M769
Resource Identification Initiative To cite this cell line use: U1/HIV-1 (RRID:CVCL_M769)
Comments Characteristics: Contains two copies of the HIV-1 proviral genome (strain HIV-NY5) per cell.
Doubling time: 36 hours (NIH-ARP).
Derived from sampling site: Pleural effusion.
Sequence variations PICALM-MLLT10 (CALM-AF10) gene fusion (from parent cell line).
Hemizygous for PTEN p.Gly129fs*51 (c.387_388insCGCC) (from parent cell line).
Homozygous for TP53 c.559+1G>A (p.Val173Trpfs*59); splice donor mutation (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line

PubMed=3313729; DOI=10.1126/science.3313729
Folks T.M., Justement J.S., Kinter A., Dinarello C.A., Fauci A.S.
Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.
Science 238:800-802(1987)

Folks T.M., Justement J.S., Kinter A., Schnittman S., Orenstein J., Poli G., Fauci A.S.
Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate.
J. Immunol. 140:1117-1122(1988)

Cell line collections NIH-ARP; 165-432
Cell line databases/resources Lonza; 1169
Other Wikidata; Q54973623
Entry history
Entry creation05-Nov-2013
Last entry update02-Jul-2020
Version number12