ID   U1/HIV-1
AC   CVCL_M769
SY   U1
DR   cancercelllines; CVCL_M769
DR   ChEMBL-Cells; CHEMBL3307351
DR   ChEMBL-Targets; CHEMBL614246
DR   HIVReagentProgram; ARP-165
DR   Lonza; 1169
DR   PubChem_Cell_line; CVCL_M769
DR   Wikidata; Q54973623
RX   PubMed=2449497;
RX   PubMed=3313729;
RX   PubMed=28086908;
CC   Population: Caucasian.
CC   Virology: Latently infected with HIV-1 isolate NY5. The two main sites of integrations are in chromosome 2 and chromosome X (PubMed=28086908).
CC   Doubling time: 36 hours (HIVReagentProgram=ARP-165).
CC   Sequence variation: Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0007 ! U-937
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 22
//
RX   PubMed=2449497; DOI=10.4049/jimmunol.140.4.1117;
RA   Folks T.M., Justement J.S., Kinter A.L., Schnittman S., Orenstein J.M.,
RA   Poli G., Fauci A.S.;
RT   "Characterization of a promonocyte clone chronically infected with HIV
RT   and inducible by 13-phorbol-12-myristate acetate.";
RL   J. Immunol. 140:1117-1122(1988).
//
RX   PubMed=3313729; DOI=10.1126/science.3313729;
RA   Folks T.M., Justement J.S., Kinter A.L., Dinarello C.A., Fauci A.S.;
RT   "Cytokine-induced expression of HIV-1 in a chronically infected
RT   promonocyte cell line.";
RL   Science 238:800-802(1987).
//
RX   PubMed=28086908; DOI=10.1186/s12977-016-0325-2;
RA   Symons J., Chopra A., Malatinkova E., De Spiegelaere W., Leary S.,
RA   Cooper D., Abana C.O., Rhodes A., Rezaei S.D., Vandekerckhove L.,
RA   Mallal S., Lewin S.R., Cameron P.U.;
RT   "HIV integration sites in latently infected cell lines: evidence of
RT   ongoing replication.";
RL   Retrovirology 14:2.1-2.11(2017).
//