ID   SUP-T1/Z29
AC   CVCL_M772
SY   SUPT-1 / Z29
DR   cancercelllines; CVCL_M772
DR   HIVReagentProgram; ARP-12183
DR   Wikidata; Q54970884
RX   PubMed=11689646;
CC   Population: Caucasian.
CC   Virology: Infected by human herpesvirus 6B (HHV-6B) strain Z29.
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
CC   Caution: Was discontinued from the HIVReagentProgram because the cell line seemed to have also been infected by HIV-1 (personal communication of Rashid S.).
CC   Discontinued: HIVReagentProgram; ARP-12183; true.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7210; Childhood T lymphoblastic lymphoma
DI   ORDO; Orphanet_171918; T-cell non-Hodgkin lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1714 ! SUP-T1
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 16
//
RX   PubMed=11689646; DOI=10.1128/JVI.75.23.11641-11650.2001;
RA   Mayne M., Cheadle C., Soldan S.S., Cermelli C., Yamano Y., Akhyani N.,
RA   Nagel J.E., Taub D.D., Becker K.G., Jacobson S.;
RT   "Gene expression profile of herpesvirus-infected T cells obtained
RT   using immunomicroarrays: induction of proinflammatory mechanisms.";
RL   J. Virol. 75:11641-11650(2001).
//