Cellosaurus logo
expasy logo

Cellosaurus TCO-1 [Human thyroid carcinoma] (CVCL_M839)

[Text version]
Cell line name TCO-1 [Human thyroid carcinoma]
Synonyms TCO-I
Accession CVCL_M839
Resource Identification Initiative To cite this cell line use: TCO-1 [Human thyroid carcinoma] (RRID:CVCL_M839)
Comments Population: Japanese.
Doubling time: ~26 hours (Note=Lot 11032003) (JCRB=JCRB0239).
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; 7773; NF2; Simple; p.Tyr101Ter (c.303T>A); Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Homozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (PubMed=30737244).
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): JCRB; PubMed=30737244

Markers:
AmelogeninX,Y
CSF1PO11
D3S135816,17
D5S81811
D7S82010,11
D8S117913
D13S31711
D16S5399,13
D18S5117
D21S1129,32.2
FGA18
TH016,7
TPOX12
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=3986962; DOI=10.1093/carcin/6.4.549
Watatani M., Ikenaga M., Hatanaka T., Kinuta M., Takai S.-i., Mori T., Kondo S.
Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA damage in tumor cell strains from Japanese patients and demonstration of MNNG hypersensitivity of Mer xenografts in athymic nude mice.
Carcinogenesis 6:549-553(1985)

PubMed=2181436; DOI=10.1073/pnas.87.7.2409
Higashi T., Sasai H., Suzuki F., Miyoshi J., Ohuchi T., Takai S.-i., Mori T., Kakunaga T.
Hamster cell line suitable for transfection assay of transforming genes.
Proc. Natl. Acad. Sci. U.S.A. 87:2409-2413(1990)

PubMed=1516062
Yoshimoto K., Iwahana H., Fukuda A., Sano T., Saito S., Itakura M.
Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction-single strand conformation polymorphism.
Cancer Res. 52:5061-5064(1992)

PubMed=9177455; DOI=10.1016/S0304-3835(97)04742-3
Satake S., Sugawara I., Watanabe M., Takami H.
Lack of a point mutation of human DNA topoisomerase II in multidrug-resistant anaplastic thyroid carcinoma cell lines.
Cancer Lett. 116:33-39(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=16924234; DOI=10.1038/sj.onc.1209899
Yu W., Imoto I., Inoue J., Onda M., Emi M., Inazawa J.
A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.
Oncogene 26:1178-1187(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. III, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line collections (Providers) JCRB; JCRB0239
JCRB; FDSC0019 - Discontinued
Cell line databases/resources cancercelllines; CVCL_M839
CGH-DB; 59-1
Biological sample resources BioSample; SAMN03471663
Encyclopedic resources Wikidata; Q54971891
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM827182
Polymorphism and mutation databases Cosmic; 909763
Cosmic; 2054090
IARC_TP53; 27018
Progenetix; CVCL_M839
Entry history
Entry creation05-Nov-2013
Last entry update05-Oct-2023
Version number26