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Cellosaurus AT3ABR (CVCL_M912)

[Text version]
Cell line name AT3ABR
Synonyms Ataxia Telangiectasia 3 Australia BRisbane
Accession CVCL_M912
Resource Identification Initiative To cite this cell line use: AT3ABR (RRID:CVCL_M912)
Comments From: Queensland Institute of Medical Research; Brisbane; Australia.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Lys2756Ter (c.8266A>T); ClinVar=VCV000135780; Zygosity=Heterozygous (PubMed=9150358).
Disease Ataxia telangiectasia syndrome (NCIt: C2887)
Ataxia telangiectasia (ORDO: Orphanet_100)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=7433105; DOI=10.1093/nar/8.16.3709
Houldsworth J., Lavin M.F.
Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells.
Nucleic Acids Res. 8:3709-3720(1980)

PubMed=6197197; DOI=10.1016/0009-2797(83)90167-9
Imray F.P., Kidson C.
Responses of Huntington's disease and ataxia telangiectasia lymphoblastoid cells to bleomycin.
Chem. Biol. Interact. 47:325-336(1983)

PubMed=6228733; DOI=10.1016/0167-8817(83)90030-5
Imray F.P., Kidson C.
Perturbations of cell-cycle progression in gamma-irradiated ataxia telangiectasia and Huntington's disease cells detected by DNA flow cytometric analysis.
Mutat. Res. 112:369-382(1983)

PubMed=6504056; DOI=10.1016/0027-5107(84)90149-0
Chen P., Imray F.P., Kidson C.
Gene dosage and complementation analysis of ataxia telangiectasia lymphoblastoid cell lines assayed by induced chromosome aberrations.
Mutat. Res. 129:165-172(1984)

PubMed=2825700; DOI=10.1016/0006-291X(87)91629-9
Mohamed R., Singh S.P., Kumar S., Lavin M.F.
A defect in DNA topoisomerase II activity in ataxia-telangiectasia cells.
Biochem. Biophys. Res. Commun. 149:233-238(1987)

PubMed=2836804; DOI=10.1093/nar/16.9.3919
Singh S.P., Mohamed R., Salmond C., Lavin M.F.
Reduced DNA topoisomerase II activity in ataxia-telangiectasia cells.
Nucleic Acids Res. 16:3919-3929(1988)

PubMed=8808599
Wright J., Teraoka S., Onengut S., Tolun A., Gatti R.A., Ochs H.D., Concannon P.
A high frequency of distinct ATM gene mutations in ataxia-telangiectasia.
Am. J. Hum. Genet. 59:839-846(1996)

PubMed=9150358; DOI=10.1038/sj.onc.1201037
Watters D., Khanna K.K., Beamish H.J., Birrell G., Spring K., Kedar P., Gatei M., Stenzel D., Hobson K., Kozlov S., Zhang N., Farrell A., Ramsay J., Gatti R.A., Lavin M.F.
Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms.
Oncogene 14:1911-1921(1997)

PubMed=9168117; DOI=10.1038/387520a0
Shafman T., Khanna K.K., Kedar P., Spring K., Kozlov S., Yen T.J., Hobson K., Gatei M., Zhang N., Watters D., Egerton M., Shiloh Y., Kharbanda S., Kufe D.W., Lavin M.F.
Interaction between ATM protein and c-Abl in response to DNA damage.
Nature 387:520-523(1997)

PubMed=11080496; DOI=10.1074/jbc.M006190200
Gueven N., Keating K.E., Chen P., Fukao T., Khanna K.K., Watters D., Rodemann P.H., Lavin M.F.
Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia.
J. Biol. Chem. 276:8884-8891(2001)

Cross-references
Encyclopedic resources Wikidata; Q54750911
Entry history
Entry creation05-Nov-2013
Last entry update29-Jun-2023
Version number17