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Cellosaurus C3ABR (CVCL_M914)

[Text version]

Cell line name C3ABR
Synonyms Control 3 Australia BRisbane
Accession CVCL_M914
Resource Identification Initiative To cite this cell line use: C3ABR (RRID:CVCL_M914)
Comments From: Queensland Institute of Medical Research; Brisbane; Australia.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from sampling site: Peripheral blood.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 63Y
Category Transformed cell line

PubMed=7433105; DOI=10.1093/nar/8.16.3709
Houldsworth J., Lavin M.F.
Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells.
Nucleic Acids Res. 8:3709-3720(1980)

PubMed=1944384; DOI=10.1016/0921-8734(91)90029-B
Chen P., Kidson C., Lavin M.F.
Heterogeneity in Alzheimer's disease: evidence from cellular radiosensitivity and complementation of this phenotype.
Mutat. Res. 256:21-27(1991)

PubMed=9150358; DOI=10.1038/sj.onc.1201037
Watters D., Khanna K.K., Beamish H.J., Birrell G., Spring K., Kedar P., Gatei M., Stenzel D., Hobson K., Kozlov S., Zhang N., Farrell A., Ramsay J., Gatti R.A., Lavin M.F.
Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms.
Oncogene 14:1911-1921(1997)

PubMed=11080496; DOI=10.1074/jbc.M006190200
Gueven N., Keating K.E., Chen P., Fukao T., Khanna K.K., Watters D., Rodemann P.H., Lavin M.F.
Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia.
J. Biol. Chem. 276:8884-8891(2001)

PubMed=12195425; DOI=10.1038/ng958
Spring K., Ahangari F., Scott S.P., Waring P., Purdie D.M., Chen P.C., Hourigan K., Ramsay J., McKinnon P.J., Swift M., Lavin M.F.
Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.
Nat. Genet. 32:185-190(2002)

PubMed=12645530; DOI=10.1074/jbc.M300003200
Kozlov S., Gueven N., Keating K.E., Ramsay J., Lavin M.F.
ATP activates ataxia-telangiectasia mutated (ATM) in vitro Importance of autophosphorylation.
J. Biol. Chem. 278:9309-9317(2003)

PubMed=15044383; DOI=10.1093/hmg/ddh122
Gueven N., Becherel O.J., Kijas A.W., Chen P., Howe O., Rudolph J.H., Gatti R.A., Date H., Onodera O., Taucher-Scholz G., Lavin M.F.
Aprataxin, a novel protein that protects against genotoxic stress.
Hum. Mol. Genet. 13:1081-1093(2004)

PubMed=16540636; DOI=10.1158/0008-5472.CAN-05-3428
Gueven N., Becherel O.J., Birrell G., Chen P., DelSal G., Carney J.P., Grattan-Smith P., Lavin M.F.
Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
Cancer Res. 66:2907-2912(2006)

PubMed=17347666; DOI=10.1038/sj.cdd.4402116
Gueven N., Becherel O.J., Howe O., Chen P., Haince J.-F., Ouellet M.-E., Poirier G.G., Waterhouse N., Fusser M., Epe B., de Murcia J.M., de Murcia G., McGowan C.H., Parton R., Mothersill C., Grattan-Smith P., Lavin M.F.
A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance.
Cell Death Differ. 14:1149-1161(2007)

PubMed=17562789; DOI=10.1083/jcb.200701042
Suraweera A., Becherel O.J., Chen P., Rundle N., Woods R., Nakamura J., Gatei M., Criscuolo C., Filla A., Chessa L., Fusser M., Epe B., Gueven N., Lavin M.F.
Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage.
J. Cell Biol. 177:969-979(2007)

PubMed=19643912; DOI=10.1093/hmg/ddp359
Harris J.L., Jakob B., Taucher-Scholz G., Dianov G.L., Becherel O.J., Lavin M.F.
Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.
Hum. Mol. Genet. 18:4102-4117(2009)

PubMed=21149446; DOI=10.1074/jbc.M110.204065
Kozlov S.V., Graham M.E., Jakob B., Tobias F., Kijas A.W., Tanuji M., Chen P., Robinson P.J., Taucher-Scholz G., Suzuki K., So S., Chen D., Lavin M.F.
Autophosphorylation and ATM activation: additional sites add to the complexity.
J. Biol. Chem. 286:9107-9119(2011)

PubMed=25868131; DOI=10.1016/j.mrgentox.2015.03.012
Kobayashi J., Saito Y., Okui M., Miwa N., Komatsu K.
Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses.
Mutat. Res. 782:42-50(2015)

Anatomy/cell type resources BTO; BTO:0006124
Encyclopedic resources Wikidata; Q54808154
Entry history
Entry creation05-Nov-2013
Last entry update12-Jan-2021
Version number10