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Cellosaurus MOVP-3 (CVCL_N031)

[Text version]

Cell line name MOVP-3
Accession CVCL_N031
Resource Identification Initiative To cite this cell line use: MOVP-3 (RRID:CVCL_N031)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0624 (MOLT-3)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line

PubMed=12623853; DOI=10.1182/blood-2002-07-2268
Schroeder U., Bernt K.M., Lange B., Wenkel J., Jikai J., Shabat D., Amir R., Huebener N., Niethammer A.G., Hagemeier C., Wiebusch L., Gaedicke G., Wrasidlo W., Reisfeld R.A., Lode H.N.
Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia.
Blood 102:246-253(2003)

Chemistry resources ChEMBL-Cells; CHEMBL3307302
ChEMBL-Targets; CHEMBL614133
Encyclopedic resources Wikidata; Q54906419
Entry history
Entry creation05-Nov-2013
Last entry update23-Jun-2022
Version number12