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Cellosaurus GIST-T1-RA2 (CVCL_QW89)

[Text version]
Cell line name GIST-T1-RA2
Synonyms GIST-RA2; RA2
Accession CVCL_QW89
Resource Identification Initiative To cite this cell line use: GIST-T1-RA2 (RRID:CVCL_QW89)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:45783; Imatinib (Gleevec; STI571).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations
  • Mutation; HGNC; 6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (from parent cell line).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4976 (GIST-T1)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Publications

PubMed=27997714; DOI=10.1002/gcc.22438
Takahashi T., Elzawahry A., Mimaki S., Furukawa E., Nakatsuka R., Nakamura H., Nishigaki T., Serada S., Naka T., Hirota S., Shibata T., Tsuchihara K., Nishida T., Kato M.
Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.
Genes Chromosomes Cancer 56:303-313(2017)

Cross-references
Encyclopedic resources Wikidata; Q54835851
Gene expression databases GEO; GSM1701542
Polymorphism and mutation databases Cosmic; 2607432
Entry history
Entry creation15-Nov-2017
Last entry update30-Jan-2024
Version number9