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Cellosaurus HaCaT siYAP (CVCL_QX09)

[Text version]
Cell line name HaCaT siYAP
Synonyms siYAP_HaCAT
Accession CVCL_QX09
Resource Identification Initiative To cite this cell line use: HaCaT siYAP (RRID:CVCL_QX09)
Comments Population: Caucasian.
Knockout cell: Method=siRNA knockdown; HGNC; 16262; YAP1.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line
Publications

PubMed=26989177; DOI=10.1242/dev.133728
Elbediwy A., Vincent-Mistiaen Z.I., Spencer-Dene B., Stone R.K., Boeing S., Wculek S.K., Cordero J., Tan E.H., Ridgway R., Brunton V.G., Sahai E., Gerhardt H., Behrens A., Malanchi I., Sansom O.J., Thompson B.J.
Integrin signalling regulates YAP and TAZ to control skin homeostasis.
Development 143:1674-1687(2016)

Cross-references
Encyclopedic resources Wikidata; Q54872313
Gene expression databases GEO; GSM2112560
GEO; GSM2112561
GEO; GSM2112562
Entry history
Entry creation15-Nov-2017
Last entry update29-Jun-2023
Version number10