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Cellosaurus A431 siYAP (CVCL_QX11)

[Text version]
Cell line name A431 siYAP
Synonyms siYAP_A431
Accession CVCL_QX11
Resource Identification Initiative To cite this cell line use: A431 siYAP (RRID:CVCL_QX11)
Comments Population: Caucasian.
Knockout cell: Method=siRNA knockdown; HGNC; 16262; YAP1.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Sequence variations
  • Gene fusion; HGNC; 3236; EGFR + HGNC; 9237; PPARGC1A; Name(s)=EGFR-PPARGC1A (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0037 (A-431)
Sex of cell Female
Age at sampling 85Y
Category Cancer cell line
Publications

PubMed=26989177; DOI=10.1242/dev.133728
Elbediwy A., Vincent-Mistiaen Z.I., Spencer-Dene B., Stone R.K., Boeing S., Wculek S.K., Cordero J., Tan E.H., Ridgway R., Brunton V.G., Sahai E., Gerhardt H., Behrens A., Malanchi I., Sansom O.J., Thompson B.J.
Integrin signalling regulates YAP and TAZ to control skin homeostasis.
Development 143:1674-1687(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_QX11
Encyclopedic resources Wikidata; Q54606911
Gene expression databases GEO; GSM2112552
GEO; GSM2112553
GEO; GSM2112554
Entry history
Entry creation15-Nov-2017
Last entry update05-Oct-2023
Version number12