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Cellosaurus RMKN-28 (CVCL_QZ55)

[Text version]

Cell line name RMKN-28
Accession CVCL_QZ55
Resource Identification Initiative To cite this cell line use: RMKN-28 (RRID:CVCL_QZ55)
Comments Problematic cell line: Contaminated. Parent cell line (MKN28) has been shown to be a MKN74 derivative.
Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar).
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Ile251Leu (c.751A>C); ClinVar=VCV000182937; Zygosity=Unspecified (PubMed=22490663).
Disease Gastric tubular adenocarcinoma (NCIt: C5473)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1416 (MKN28)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Publications

PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122
Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M., Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S., Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M., Ishida M., Motoi F., Egawa S., Unno M., Horii A.
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochem. Biophys. Res. Commun. 421:98-104(2012)

Cross-references
Other Wikidata; Q54950673
Entry history
Entry creation05-Mar-2018
Last entry update20-May-2021
Version number4