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Cellosaurus J.CaM2 (CVCL_R862)

[Text version]

Cell line name J.CaM2
Synonyms JCaM2; JCam2; Jurkat-derived Ca2+ mutant no. 2
Accession CVCL_R862
Resource Identification Initiative To cite this cell line use: J.CaM2 (RRID:CVCL_R862)
Comments Transformant: NCIt; C129643; Cesium-137 gamma radiation.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for BAX p.Glu41Argfs (c.121delG) and p.Glu41Glyfs (c.121dupG) (from parent cell line).
Heterozygous for FBXW7 p.Arg505Cys (c.1513C>T) (from parent cell line).
Heterozygous for INPP5D p.Gln345Ter (c.1033C>T) and c.1097+1065_1097+1112del47 (from parent cell line).
Homozygous for MSH2 p.Arg711Ter (c.2131C>T) (from parent cell line).
Homozygous for MSH6 p.Phe1088Serfs*2 (c.3261delC) (from parent cell line).
Heterozygous for SYK p.Met34Hisfs*3 (c.98_99insG) (from parent cell line).
Heterozygous for TP53 p.Arg196Ter (c.586C>T) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0367 (Jurkat E6.1)
Children:
CVCL_DR61 (J.CaM2.5)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=3263650; DOI=10.1073/pnas.85.22.8613
Goldsmith M.A., Dazin P.F., Weiss A.
At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.
Proc. Natl. Acad. Sci. U.S.A. 85:8613-8617(1988)

PubMed=9846483; DOI=10.1016/S1074-7613(00)80659-7
Finco T.S., Kadlecek T., Zhang W., Samelson L.E., Weiss A.
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
Immunity 9:617-626(1998)

Cross-references
Other Wikidata; Q54898428
Entry history
Entry creation05-Nov-2013
Last entry updated24-May-2019
Version number10