ID   J.CaM2
AC   CVCL_R862
SY   JCaM2; JCam2; Jurkat-derived Ca2+ mutant no. 2
DR   cancercelllines; CVCL_R862
DR   Wikidata; Q54898428
RX   PubMed=3263650;
RX   PubMed=9846483;
RX   PubMed=27278128;
RX   PubMed=33562083;
CC   Population: Caucasian.
CC   Characteristics: Lacks LAT expression.
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 18874; LAT; Simple; g.237C>T; Zygosity=Heterozygous (PubMed=27278128; PubMed=33562083).
CC   Sequence variation: Mutation; HGNC; 18874; LAT; Simple; p.Thr56Met (c.167C>T); ClinVar=VCV001493770; Zygosity=Heterozygous (PubMed=27278128; PubMed=33562083).
CC   Sequence variation: Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: NCIt; C129643; Cesium-137 gamma radiation.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0367 ! Jurkat E6.1
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 30-01-24; Version: 20
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RX   PubMed=3263650; DOI=10.1073/pnas.85.22.8613;
RA   Goldsmith M.A., Dazin P.F., Weiss A.;
RT   "At least two non-antigen-binding molecules are required for signal
RT   transduction by the T-cell antigen receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:8613-8617(1988).
//
RX   PubMed=9846483; DOI=10.1016/S1074-7613(00)80659-7;
RA   Finco T.S., Kadlecek T., Zhang W.-G., Samelson L.E., Weiss A.;
RT   "LAT is required for TCR-mediated activation of PLCgamma1 and the Ras
RT   pathway.";
RL   Immunity 9:617-626(1998).
//
RX   PubMed=27278128; DOI=10.1038/gene.2016.25;
RA   Marek-Bukowiec K., Aguado E., Miazek A.;
RT   "Phorbol ester-mediated re-expression of endogenous LAT adapter in
RT   J.CaM2 cells: a model for dissecting drivers and blockers of LAT
RT   transcription.";
RL   Genes Immun. 17:313-320(2016).
//
RX   PubMed=33562083; DOI=10.3390/cells10020343;
RA   Vico-Barranco I., de Arbulo-Echevarria M.M., Serrano-Garcia I.,
RA   Perez-Linaza A., Miranda-Sayago J.M., Miazek A., Narbona-Sanchez I.,
RA   Aguado E.;
RT   "A novel, LAT/Lck double deficient T cell subline J.CaM1.7 for
RT   combined analysis of early TCR signaling.";
RL   Cells 10:343.1-343.20(2021).
//