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Cellosaurus VCaP-EnzR (CVCL_RA58)

[Text version]

Cell line name VCaP-EnzR
Accession CVCL_RA58
Resource Identification Initiative To cite this cell line use: VCaP-EnzR (RRID:CVCL_RA58)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:68534; Enzalutamide (Xtandi; MDV-3100).
Omics: Transcriptome analysis.
Sequence variations
  • Gene fusion; HGNC; 3446; ERG + HGNC; 11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
  • Mutation; HGNC; 7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Bone; vertebra.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2235 (VCaP)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=27036029; DOI=10.18632/oncotarget.8456
Kregel S., Chen J.L., Tom W., Krishnan V., Kach J., Brechka H., Fessenden T.B., Isikbay M., Paner G.P., Szmulewitz R.Z., Vander Griend D.J.
Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer.
Oncotarget 7:26259-26274(2016)

Cross-references
Cell line collections Millipore; SCC421
Encyclopedic resources Wikidata; Q54992965
Gene expression databases GEO; GSM2069538
GEO; GSM2069539
GEO; GSM2069540
GEO; GSM2069541
Entry history
Entry creation05-Mar-2018
Last entry update23-Sep-2021
Version number10