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Cellosaurus MDA-MB-231 shPARG (CVCL_RA90)

[Text version]

Cell line name MDA-MB-231 shPARG
Synonyms shPARG MDA-MB-231
Accession CVCL_RA90
Resource Identification Initiative To cite this cell line use: MDA-MB-231 shPARG (RRID:CVCL_RA90)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Knockout cell: Method=shRNA knockdown; HGNC; 8605; PARG.
Omics: Poly-ADP-ribosylation by proteomics.
Sequence variations Heterozygous for BRAF p.Gly464Val (c.1391G>T) (ClinVar=VCV000040364) (from parent cell line).
Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Arg280Lys (c.839G>A) (ClinVar=VCV000376657) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=29166620; DOI=10.1016/j.celrep.2017.10.106
Zhen Y.-L., Zhang Y.-J., Yu Y.-H.
A cell-line-specific atlas of PARP-mediated protein Asp/Glu-ADP-ribosylation in breast cancer.
Cell Rep. 21:2326-2337(2017)

Cross-references
Other Wikidata; Q54904589
Entry history
Entry creation05-Mar-2018
Last entry update02-Jul-2020
Version number5