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Cellosaurus MDA-MB-468 shPARG (CVCL_RA91)

[Text version]

Cell line name MDA-MB-468 shPARG
Synonyms shPARG MDA-MB-468
Accession CVCL_RA91
Resource Identification Initiative To cite this cell line use: MDA-MB-468 shPARG (RRID:CVCL_RA91)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Knockout cell: Method=shRNA knockdown; HGNC; 8605; PARG.
Omics: Poly-ADP-ribosylation by proteomics.
Sequence variations Homozygous for PTEN c.253+1G>T; splice donor mutation (from parent cell line).
Homozygous for RB1 c.265_2787del2523 (from parent cell line).
Homozygous for TP53 p.Arg273His (c.818G>A) (ClinVar=VCV000012366) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0419 (MDA-MB-468)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

PubMed=29166620; DOI=10.1016/j.celrep.2017.10.106
Zhen Y.-L., Zhang Y.-J., Yu Y.-H.
A cell-line-specific atlas of PARP-mediated protein Asp/Glu-ADP-ribosylation in breast cancer.
Cell Rep. 21:2326-2337(2017)

Other Wikidata; Q54904644
Entry history
Entry creation05-Mar-2018
Last entry updated02-Jul-2020
Version number6