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Cellosaurus STBCi004-B (CVCL_RB35)

[Text version]
Cell line name STBCi004-B
Synonyms SFC832-03-06
Accession CVCL_RB35
Resource Identification Initiative To cite this cell line use: STBCi004-B (RRID:CVCL_RB35)
Comments From: StemBANCC; Oxford; United Kingdom.
Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; 18618; LRRK2; Simple; p.Gly2019Ser (c.6055G>A); ClinVar=VCV000001940; Zygosity=Heterozygous (PubMed=32359446).
Disease Parkinson disease 8, autosomal dominant (NCIt: C198605)
Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A8X1 (STBCi004-B-1)
Originate from same individual CVCL_RB34 ! STBCi004-A
CVCL_RB36 ! STBCi004-C
Sex of cell Female
Age at sampling 77Y
Category Induced pluripotent stem cell
Publications

PubMed=32359446; DOI=10.1016/j.stemcr.2020.04.001
Lee H., Flynn R., Sharma I., Haberman E., Carling P.J., Nicholls F.J., Stegmann M., Vowles J., Haenseler W., Wade-Martins R., James W.S., Cowley S.A.
LRRK2 is recruited to phagosomes and co-recruits RAB8 and RAB10 in human pluripotent stem cell-derived macrophages.
Stem Cell Reports 14:940-955(2020)

Cross-references
Cell line collections (Providers) EBiSC; STBCi004-B - Discontinued
ECACC; 66540905 - Discontinued
Cell line databases/resources hPSCreg; STBCi004-B
Biological sample resources BioSamples; SAMEA104615892
Encyclopedic resources Wikidata; Q54956326
Entry history
Entry creation05-Mar-2018
Last entry update30-Jan-2024
Version number12