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Cellosaurus HaCaT-TRS4 (CVCL_RL61)

[Text version]

Cell line name HaCaT-TRS4
Accession CVCL_RL61
Resource Identification Initiative To cite this cell line use: HaCaT-TRS4 (RRID:CVCL_RL61)
Comments Characteristics: Expresses tetracyclin-inducible SMAD4 siRNA.
Knockout cell: Method=siRNA knockdown; HGNC; 6770; SMAD4.
Transfected with: UniProtKB; P04483; E.coli Tn10 tetR.
Derived from sampling site: Back; skin; epidermis; keratinocyte.
Sequence variations Heterozygous for TP53 p.His179Tyr (c.535C>T) (ClinVar=VCV000127815) (from parent cell line).
Heterozygous for TP53 p.Arg282Trp (c.843_844CC>TT) (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line
Publications

PubMed=16135802; DOI=10.1128/MCB.25.18.8108-8125.2005
Levy L., Hill C.S.
Smad4 dependency defines two classes of transforming growth factor beta (TGF-beta) target genes and distinguishes TGF-beta-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.
Mol. Cell. Biol. 25:8108-8125(2005)

Cross-references
Other Wikidata; Q54872316
Entry history
Entry creation05-Mar-2018
Last entry update12-Jan-2021
Version number5