ID   HaCaT-TRS4
AC   CVCL_RL61
DR   Wikidata; Q54872316
RX   PubMed=16135802;
CC   Population: Caucasian.
CC   Characteristics: Expresses tetracyclin-inducible SMAD4 siRNA.
CC   Knockout cell: Method=siRNA knockdown; HGNC; 6770; SMAD4.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0038 ! HaCaT
SX   Male
AG   62Y
CA   Spontaneously immortalized cell line
DT   Created: 05-03-18; Last updated: 29-06-23; Version: 10
//
RX   PubMed=16135802; DOI=10.1128/mcb.25.18.8108-8125.2005;
RA   Levy L., Hill C.S.;
RT   "Smad4 dependency defines two classes of transforming growth factor
RT   beta (TGF-beta) target genes and distinguishes TGF-beta-induced
RT   epithelial-mesenchymal transition from its antiproliferative and
RT   migratory responses.";
RL   Mol. Cell. Biol. 25:8108-8125(2005).
//