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Cellosaurus HCT 116 PIK3CA H1047R KO (CVCL_RQ06)

[Text version]

Cell line name HCT 116 PIK3CA H1047R KO
Synonyms PIK3CA^(+/-) HCT116
Accession CVCL_RQ06
Resource Identification Initiative To cite this cell line use: HCT 116 PIK3CA H1047R KO (RRID:CVCL_RQ06)
Comments Characteristics: Knockout of PIK3CA mutant allele (H1047R) in heterozygous parental cells.
Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 8975; PIK3CA (with p.His1047Arg).
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for BRCA2 p.Ile2675fs*6 (c.8021_8022insA) (from parent cell line).
Heterozygous for CDKN2A p.Arg24fs*20 (c.68_69insG) and p.Glu74fs*15 (c.220delG) (from parent cell line).
Heterozygous for CTNNB1 p.Ser45del (c.133_135delTCT) (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0291 (HCT 116)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-pik3ca-hct116-cell-line-hd-104-007

PubMed=15950905; DOI=10.1016/j.ccr.2005.05.014
Samuels Y., Diaz L.A. Jr., Schmidt-Kittler O., Cummins J.M., Delong L., Cheong I., Rago C., Huso D.L., Lengauer C., Kinzler K.W., Vogelstein B., Velculescu V.E.
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Cancer Cell 7:561-573(2005)

Other Wikidata; Q54881975
Entry history
Entry creation05-Mar-2018
Last entry updated07-Sep-2018
Version number3