ID   HCT 116 PIK3CA H1047R KO
AC   CVCL_RQ06
SY   PIK3CA^(+/-) HCT116
DR   Wikidata; Q54881975
RX   PubMed=15950905;
WW   https://www.horizondiscovery.com/human-pik3ca-hct116-cell-line-hd-104-007
CC   Characteristics: Knockout of PIK3CA mutant allele (H1047R) in heterozygous parental cells.
CC   Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 8975; PIK3CA (with p.His1047Arg).
CC   Sequence variation: Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
CC   Sequence variation: Heterozygous for BRCA2 p.Ile2675fs*6 (c.8021_8022insA) (from parent cell line).
CC   Sequence variation: Heterozygous for CDKN2A p.Arg24fs*20 (c.68_69insG) and p.Glu74fs*15 (c.220delG) (from parent cell line).
CC   Sequence variation: Heterozygous for CTNNB1 p.Ser45del (c.133_135delTCT) (from parent cell line).
CC   Sequence variation: Heterozygous for KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
CC   Sequence variation: Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 07-09-18; Version: 3
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RX   PubMed=15950905; DOI=10.1016/j.ccr.2005.05.014;
RA   Samuels Y., Diaz L.A. Jr., Schmidt-Kittler O., Cummins J.M.,
RA   Delong L., Cheong I., Rago C., Huso D.L., Lengauer C., Kinzler K.W.,
RA   Vogelstein B., Velculescu V.E.;
RT   "Mutant PIK3CA promotes cell growth and invasion of human cancer
RT   cells.";
RL   Cancer Cell 7:561-573(2005).
//