ID   HCT 116 PIK3CA H1047R KO
AC   CVCL_RQ06
SY   PIK3CA^(+/-) HCT116
DR   cancercelllines; CVCL_RQ06
DR   Horizon_Discovery; HD+104-007
DR   Wikidata; Q54881975
RX   PubMed=15950905;
CC   Population: Caucasian.
CC   Characteristics: Knockout of PIK3CA mutant allele (H1047R) in heterozygous parental cells.
CC   Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 8975; PIK3CA (Note=With p.His1047Arg).
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 30-01-24; Version: 11
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RX   PubMed=15950905; DOI=10.1016/j.ccr.2005.05.014;
RA   Samuels Y., Diaz L.A. Jr., Schmidt-Kittler O., Cummins J.M.,
RA   DeLong L., Cheong I., Rago C., Huso D.L., Lengauer C., Kinzler K.W.,
RA   Vogelstein B., Velculescu V.E.;
RT   "Mutant PIK3CA promotes cell growth and invasion of human cancer
RT   cells.";
RL   Cancer Cell 7:561-573(2005).
//