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Cellosaurus HT1376rCDDP1000 (CVCL_RR15)

Cell line name HT1376rCDDP1000
Accession CVCL_RR15
Resource Identification Initiative To cite this cell line use: HT1376rCDDP1000 (RRID:CVCL_RR15)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Doubling time: 31.2 hours (PubMed=26055179).
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Sequence variations Homozygous for RB1 p.Gln702Ter (c.2104C>T) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
TP53 p.Pro250Leu (c.749C>T) (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1292 (HT-1376)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Web pages http://www.wass-michaelislab.org/rccl.php
Publications

PubMed=26055179; DOI=10.1016/j.tranon.2015.04.002
Vallo S., Michaelis M., Rothweiler F., Bartsch G., Gust K.M., Limbart D.M., Rodel F., Wezel F., Haferkamp A., Cinatl J. Jr.
Drug-resistant urothelial cancer cell lines display diverse sensitivity profiles to potential second-line therapeutics.
Transl. Oncol. 8:210-216(2015)

Cross-references
Other Wikidata; Q54896571