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Cellosaurus UKF-NB-3rDOX20 (CVCL_RS04)

[Text version]

Cell line name UKF-NB-3rDOX20
Accession CVCL_RS04
Resource Identification Initiative To cite this cell line use: UKF-NB-3rDOX20 (RRID:CVCL_RS04)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Doubling time: 18 +- 1.9 hours (PubMed=16142320).
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Disease Neuroblastoma (NCIt: C3270)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9904 (UKF-NB-3)
Category Cancer cell line
Web pages http://www.wass-michaelislab.org/rccl.php
Publications

PubMed=16142320; DOI=10.3892/ijo.27.4.1029
Kotchetkov R., Driever P.H., Cinatl J., Michaelis M., Karaskova J., Blaheta R.A., Squire J.A., von Deimling A., Moog J., Cinatl J. Jr.
Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression.
Int. J. Oncol. 27:1029-1037(2005)

PubMed=19147553; DOI=10.1158/0008-5472.CAN-08-1856
Michaelis M., Rothweiler F., Klassert D., von Deimling A., Weber K., Fehse B., Kammerer B., Doerr H.-W., Cinatl J. Jr.
Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3.
Cancer Res. 69:416-421(2009)

PubMed=22170099; DOI=10.1038/cddis.2011.129
Michaelis M., Rothweiler F., Barth S., Cinatl J., van Rikxoort M., Loschmann N., Voges Y., Breitling R., von Deimling A., Rodel F., Weber K., Fehse B., Mack E., Stiewe T., Doerr H.-W., Speidel D., Cinatl J. Jr.
Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.
Cell Death Dis. 2:E243-E243(2011)

PubMed=27517323; DOI=10.18632/oncotarget.11160
Loschmann N., Michaelis M., Rothweiler F., Voges Y., Balonova B., Blight B.A., Cinatl J. Jr.
ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance.
Oncotarget 7:58051-58064(2016)

Cross-references
Other Wikidata; Q54990339
Entry history
Entry creation05-Mar-2018
Last entry updated07-Sep-2018
Version number2