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Cellosaurus H82R (CVCL_RS66)

[Text version]
Cell line name H82R
Accession CVCL_RS66
Resource Identification Initiative To cite this cell line use: H82R (RRID:CVCL_RS66)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Thr125Thr (c.375G>T); ClinVar=VCV000237948; Zygosity=Unspecified; Note=Impairs TP53 splicing dramatically (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1591 (NCI-H82)
Sex of cell Male
Age at sampling 41Y
Category Cancer cell line
Publications

PubMed=27610620; DOI=10.1371/journal.pone.0162925
Yan F., Pang J.-X., Peng Y., Molina J.R., Yang P., Liu S.-J.
Elevated cellular PD1/PD-L1 expression confers acquired resistance to cisplatin in small cell lung cancer cells.
PLoS ONE 11:E0162925-E0162925(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RS66
Encyclopedic resources Wikidata; Q54872227
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number11