Home  |  Contact

Cellosaurus H446/CDDP (CVCL_RT21)

[Text version]
Cell line name H446/CDDP
Synonyms H446/DDP
Accession CVCL_RT21
Resource Identification Initiative To cite this cell line use: H446/CDDP (RRID:CVCL_RT21)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Omics: miRNA expression profiling.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 6728; LY6H + HGNC; 9709; PVT1; Name(s)=PVT1-LY6H (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly154Val (c.461G>T); ClinVar=VCV000651769; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1562 (NCI-H446)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Publications

PubMed=16677475; DOI=10.3760/j:issn:1001-0939.2006.03.005
Ji F.-Y., Qian G.-S., Qian P., Chen Y., Guo R.-L., Li S.-P., Huang G.-J.
Involvement of bcl-2 in multidrug resistance in human small cell lung cancer cell subline H446/DDP.
Zhonghua Jie He He Hu Xi Za Zhi 29:156-160(2006)

PubMed=19360300; DOI=10.3892/or_00000347
Li S.-J., Bao P.-T., Li Z.-K., Ouyang H.-F., Wu C.-G., Qian G.-S.
Inhibition of proliferation and apoptosis induced by a Na+/H+ exchanger-1 (NHE-1) antisense gene on drug-resistant human small cell lung cancer cells.
Oncol. Rep. 21:1243-1249(2009)

PubMed=26676926; DOI=10.3892/or.2015.4487
Ma L.-J., Li P.-P., Wang R.-X., Nan Y.-D., Liu X.-Y., Jin F.-G.
Analysis of novel microRNA targets in drug-sensitive and -insensitive small cell lung cancer cell lines.
Oncol. Rep. 35:1611-1621(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RT21
Encyclopedic resources Wikidata; Q54872145
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number11