ID   H446/CDDP
AC   CVCL_RT21
SY   H446/DDP
DR   cancercelllines; CVCL_RT21
DR   Wikidata; Q54872145
RX   PubMed=16677475;
RX   PubMed=19360300;
RX   PubMed=26676926;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
CC   Sequence variation: Gene fusion; HGNC; 6728; LY6H + HGNC; 9709; PVT1; Name(s)=PVT1-LY6H (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly154Val (c.461G>T); ClinVar=VCV000651769; Zygosity=Homozygous (from parent cell line).
CC   Omics: miRNA expression profiling.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1562 ! NCI-H446
SX   Male
AG   61Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 05-10-23; Version: 11
//
RX   PubMed=16677475; DOI=10.3760/j:issn:1001-0939.2006.03.005;
RA   Ji F.-Y., Qian G.-S., Qian P., Chen Y., Guo R.-L., Li S.-P.,
RA   Huang G.-J.;
RT   "Involvement of bcl-2 in multidrug resistance in human small cell lung
RT   cancer cell subline H446/DDP.";
RL   Zhonghua Jie He He Hu Xi Za Zhi 29:156-160(2006).
//
RX   PubMed=19360300; DOI=10.3892/or_00000347;
RA   Li S.-J., Bao P.-T., Li Z.-K., Ouyang H.-F., Wu C.-G., Qian G.-S.;
RT   "Inhibition of proliferation and apoptosis induced by a Na+/H+
RT   exchanger-1 (NHE-1) antisense gene on drug-resistant human small cell
RT   lung cancer cells.";
RL   Oncol. Rep. 21:1243-1249(2009).
//
RX   PubMed=26676926; DOI=10.3892/or.2015.4487;
RA   Ma L.-J., Li P.-P., Wang R.-X., Nan Y.-D., Liu X.-Y., Jin F.-G.;
RT   "Analysis of novel microRNA targets in drug-sensitive and -insensitive
RT   small cell lung cancer cell lines.";
RL   Oncol. Rep. 35:1611-1621(2016).
//