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Cellosaurus PPT2 (CVCL_RU11)

[Text version]
Cell line name PPT2
Accession CVCL_RU11
Resource Identification Initiative To cite this cell line use: PPT2 (RRID:CVCL_RU11)
Comments Problematic cell line: Contaminated. Shown to be a HCT 116 derivative (STR profile). Originally thought to originate from a male patient with prostate carcinoma.
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0291 (HCT 116)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): Millipore

Markers:
AmelogeninX
CSF1PO7,10
D3S135812,18,19
D5S81810,11
D7S82011,12
D8S117912,14
D13S31710,11,13
D16S53911,13,14
D18S5117,18
D21S1129,30
FGA18,22,23
Penta D9,13
Penta E13,14
TH018,9
TPOX8
vWA17,18,21,22

Run an STR similarity search on this cell line
Publications

PubMed=24086245; DOI=10.1371/journal.pone.0069884
Botchkina G.I., Zuniga E.S., Rowehl R.A., Park R., Bhalla R., Bialkowska A.B., Johnson F., Golub L.M., Zhang Y., Ojima I., Shroyer K.R.
Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24.
PLoS ONE 8:E69884-E69884(2013)

Cross-references
Cell line collections (Providers) Millipore; SCC104 - Discontinued
Cell line databases/resources cancercelllines; CVCL_RU11
Encyclopedic resources Wikidata; Q54947804
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number9