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Cellosaurus MR42D (CVCL_RW50)

[Text version]

Cell line name MR42D
Synonyms ENZR 42D; 42DENZR
Accession CVCL_RW50
Resource Identification Initiative To cite this cell line use: MR42D (RRID:CVCL_RW50)
Comments Selected for resistance to: ChEBI; CHEBI:68534; Enzalutamide (Xtandi; MDV-3100).
Sequence variations Homozygous for AR p.Thr878Ala (c.2632A>G) (from parent cell line).
Heterozygous for MEN1 p.Tyr313Ter (c.939T>A) (from parent cell line).
Heterozygous for PIK3R1 p.Arg639Ter (c.1915C>T) (from parent cell line).
PTEN p.Lys6Argfs*4 (c.17_18delAA) (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=25428917; DOI=10.18632/oncotarget.2703
Bishop J.L., Sio A., Angeles A., Roberts M.E., Azad A.A., Chi K.N., Zoubeidi A.
PD-L1 is highly expressed in Enzalutamide resistant prostate cancer.
Oncotarget 6:234-242(2015)

Cross-references
Other Wikidata; Q54906571
Entry history
Entry creation05-Mar-2018
Last entry update02-Jul-2020
Version number4