ID   MR49F
AC   CVCL_RW53
SY   MR49-F; ENZR 49F; 49FENZR
DR   BTO; BTO:0006265
DR   cancercelllines; CVCL_RW53
DR   ChEMBL-Cells; CHEMBL4483149
DR   ChEMBL-Targets; CHEMBL4483259
DR   PubChem_Cell_line; CVCL_RW53
DR   Wikidata; Q54906576
RX   PubMed=25428917;
RX   PubMed=25634993;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:68534; Enzalutamide (Xtandi; MDV-3100).
CC   Sequence variation: Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0395 ! LNCaP
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 05-10-23; Version: 11
//
RX   PubMed=25428917; DOI=10.18632/oncotarget.2703;
RA   Bishop J.L., Sio A., Angeles A., Roberts M.E., Azad A.A., Chi K.N.,
RA   Zoubeidi A.;
RT   "PD-L1 is highly expressed in Enzalutamide resistant prostate
RT   cancer.";
RL   Oncotarget 6:234-242(2015).
//
RX   PubMed=25634993; DOI=10.1158/1078-0432.CCR-14-1108;
RA   Yamamoto Y., Loriot Y., Beraldi E., Zhang F., Wyatt A.W.,
RA   Al Nakouzi N., Mo F., Zhou T.-Y., Kim Y., Monia B.P., MacLeod A.R.,
RA   Fazli L., Wang Y.-Z., Collins C.C., Zoubeidi A., Gleave M.E.;
RT   "Generation 2.5 antisense oligonucleotides targeting the androgen
RT   receptor and its splice variants suppress enzalutamide-resistant
RT   prostate cancer cell growth.";
RL   Clin. Cancer Res. 21:1675-1687(2015).
//