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Cellosaurus Capan-1 SimpleCell O-GalNAc (CVCL_S022)

[Text version]

Cell line name Capan-1 SimpleCell O-GalNAc
Synonyms Capan-1 SimpleCell; Capan-1 SC
Accession CVCL_S022
Resource Identification Initiative To cite this cell line use: Capan-1 SimpleCell O-GalNAc (RRID:CVCL_S022)
Comments Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1.
Sequence variations Hemizygous for BRCA2 p.Ser1982Argfs*22 (c.5946delT) (6174delT) (ClinVar=VCV000009325) (from parent cell line).
Homozygous for FZD10 p.Asn54Lys (c.162C>A) (from parent cell line).
Heterozygous for GLT6D1 p.Trp198Ter (c.593G>A) (from parent cell line).
Homozygous for GRM1 p.Tyr486Ter (c.1458C>A) (from parent cell line).
Homozygous for KRAS p.Gly12Val (c.35G>T) (ClinVar=VCV000012583) (from parent cell line).
Homozygous for MAP2K4 p.Glu221Ter (c.661G>T) (from parent cell line).
Homozygous for SMAD4 p.Ser243Ter (c.1028C>G) (from parent cell line).
Heterozygous for SMAP2 p.Ser255Ter (c.764C>G) (from parent cell line).
TP53 p.Ala159Val (c.476C>T) (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0237 (Capan-1)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line

PubMed=21983924; DOI=10.1038/nmeth.1731
Steentoft C., Vakhrushev S.Y., Vester-Christensen M.B., Schjoldager K.T., Kong Y., Bennett E.P., Mandel U., Wandall H.H., Levery S.B., Clausen H.
Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines.
Nat. Methods 8:977-982(2011)

PubMed=23399548; DOI=10.1074/mcp.O112.021972
Vakhrushev S.Y., Steentoft C., Vester-Christensen M.B., Bennett E.P., Clausen H., Levery S.B.
Enhanced mass spectrometric mapping of the human GalNAc-type O-glycoproteome with SimpleCells.
Mol. Cell. Proteomics 12:932-944(2013)

PubMed=23584533; DOI=10.1038/emboj.2013.79
Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.
EMBO J. 32:1478-1488(2013)

Other Wikidata; Q54808590
Entry history
Entry creation05-Nov-2013
Last entry update02-Jul-2020
Version number15