ID   Capan-1 SimpleCell O-GalNAc
AC   CVCL_S022
SY   Capan-1 SimpleCell; Capan-1 SC
DR   cancercelllines; CVCL_S022
DR   Wikidata; Q54808590
RX   PubMed=21983924;
RX   PubMed=23399548;
RX   PubMed=23584533;
CC   Population: Caucasian.
CC   Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
CC   Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1.
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Ser1982Argfs*22 (c.5946delT) (6174delT); ClinVar=VCV000009325; Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4039; FZD10; Simple; p.Asn54Lys (c.162C>A); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 23671; GLT6D1; Simple; p.Trp198Ter (c.593G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4593; GRM1; Simple; p.Tyr486Ter (c.1458C>A); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6844; MAP2K4; Simple; p.Glu221Ter (c.661G>T); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Ser343Ter (c.1028C>G); ClinVar=VCV000822036; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 25082; SMAP2; Simple; p.Ser255Ter (c.764C>G); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ala159Val (c.476C>T); ClinVar=VCV000458545; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0237 ! Capan-1
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 22
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RX   PubMed=21983924; DOI=10.1038/nmeth.1731;
RA   Steentoft C., Vakhrushev S.Y., Vester-Christensen M.B.,
RA   Schjoldager K.T.-B.G., Kong Y., Bennett E.P., Mandel U., Wandall H.H.,
RA   Levery S.B., Clausen H.;
RT   "Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered
RT   SimpleCell lines.";
RL   Nat. Methods 8:977-982(2011).
//
RX   PubMed=23399548; DOI=10.1074/mcp.O112.021972;
RA   Vakhrushev S.Y., Steentoft C., Vester-Christensen M.B., Bennett E.P.,
RA   Clausen H., Levery S.B.;
RT   "Enhanced mass spectrometric mapping of the human GalNAc-type
RT   O-glycoproteome with SimpleCells.";
RL   Mol. Cell. Proteomics 12:932-944(2013).
//
RX   PubMed=23584533; DOI=10.1038/emboj.2013.79;
RA   Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y.,
RA   Vester-Christensen M.B., Schjoldager K.T.-B.G., Lavrsen K.,
RA   Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P.,
RA   Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.;
RT   "Precision mapping of the human O-GalNAc glycoproteome through
RT   SimpleCell technology.";
RL   EMBO J. 32:1478-1488(2013).
//