ID   COLO 205 SimpleCell O-GalNAc
AC   CVCL_S023
SY   Colo205 SimpleCell; Colo205 SC
DR   cancercelllines; CVCL_S023
DR   Wikidata; Q54814075
RX   PubMed=21983924;
RX   PubMed=23399548;
RX   PubMed=23584533;
CC   Population: Caucasian.
CC   Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
CC   Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Asn287Ser (c.860A>G); ClinVar=VCV000133954; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr103fs*37 (c.308_321delTGTGTAACAGTTCC); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0218 ! COLO 205
SX   Male
AG   70Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 20
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RX   PubMed=21983924; DOI=10.1038/nmeth.1731;
RA   Steentoft C., Vakhrushev S.Y., Vester-Christensen M.B.,
RA   Schjoldager K.T.-B.G., Kong Y., Bennett E.P., Mandel U., Wandall H.H.,
RA   Levery S.B., Clausen H.;
RT   "Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered
RT   SimpleCell lines.";
RL   Nat. Methods 8:977-982(2011).
//
RX   PubMed=23399548; DOI=10.1074/mcp.O112.021972;
RA   Vakhrushev S.Y., Steentoft C., Vester-Christensen M.B., Bennett E.P.,
RA   Clausen H., Levery S.B.;
RT   "Enhanced mass spectrometric mapping of the human GalNAc-type
RT   O-glycoproteome with SimpleCells.";
RL   Mol. Cell. Proteomics 12:932-944(2013).
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RX   PubMed=23584533; DOI=10.1038/emboj.2013.79;
RA   Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y.,
RA   Vester-Christensen M.B., Schjoldager K.T.-B.G., Lavrsen K.,
RA   Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P.,
RA   Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.;
RT   "Precision mapping of the human O-GalNAc glycoproteome through
RT   SimpleCell technology.";
RL   EMBO J. 32:1478-1488(2013).
//