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Cellosaurus Hep-G2 SimpleCell O-GalNAc (CVCL_S027)

[Text version]

Cell line name Hep-G2 SimpleCell O-GalNAc
Synonyms HepG2 SimpleCell; HepG2 SC; HepG2SC
Accession CVCL_S027
Resource Identification Initiative To cite this cell line use: Hep-G2 SimpleCell O-GalNAc (RRID:CVCL_S027)
Comments Population: Caucasian.
Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1.
Derived from sampling site: Liver.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
CVCL_EI11 (Hep-G2 SimpleCell O-GalNAc KI GalNAc-T3 )CVCL_EI09 (Hep-G2 SimpleCell O-GalNAc KO GalNAc-T1 )CVCL_EI10 (Hep-G2 SimpleCell O-GalNAc KO GalNAc-T2 )
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line

PubMed=23584533; DOI=10.1038/emboj.2013.79
Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T.-B.G., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.
EMBO J. 32:1478-1488(2013)

PubMed=26566661; DOI=10.15252/embr.201540796
Schjoldager K.T.-B.G., Joshi H.J., Kong Y., Goth C.K., King S.L., Wandall H.H., Bennett E.P., Vakhrushev S.Y., Clausen H.
Deconstruction of O-glycosylation -- GalNAc-T isoforms direct distinct subsets of the O-glycoproteome.
EMBO Rep. 16:1713-1722(2015)

Encyclopedic resources Wikidata; Q54882782
Entry history
Entry creation05-Nov-2013
Last entry update20-May-2021
Version number17