ID   Hep-G2 SimpleCell O-GalNAc
AC   CVCL_S027
SY   HepG2 SimpleCell; HepG2 SC; HepG2SC
DR   Wikidata; Q54882782
RX   PubMed=23584533;
RX   PubMed=26566661;
CC   Population: Caucasian.
CC   Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
CC   Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from sampling site: Liver.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 20-05-21; Version: 17
RX   PubMed=23584533; DOI=10.1038/emboj.2013.79;
RA   Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y.,
RA   Vester-Christensen M.B., Schjoldager K.T.-B.G., Lavrsen K.,
RA   Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P.,
RA   Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.;
RT   "Precision mapping of the human O-GalNAc glycoproteome through
RT   SimpleCell technology.";
RL   EMBO J. 32:1478-1488(2013).
RX   PubMed=26566661; DOI=10.15252/embr.201540796;
RA   Schjoldager K.T.-B.G., Joshi H.J., Kong Y., Goth C.K., King S.L.,
RA   Wandall H.H., Bennett E.P., Vakhrushev S.Y., Clausen H.;
RT   "Deconstruction of O-glycosylation -- GalNAc-T isoforms direct distinct
RT   subsets of the O-glycoproteome.";
RL   EMBO Rep. 16:1713-1722(2015).